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Constitution Avenue - Wikipedia

https://en.wikipedia.org/wiki/Constitution_Avenue

Constitution Avenue is a major east-west street in the northwest and northeast quadrants of the ... TheWashington Canal Company was incorporated in 1802, and after several false starts substantial work began in 1810. ..... Roosevelt Bridge; thus, Constitution Avenue connects the city's ceremonial core withInterstate 66.

West end‎: ‎US 50‎ (‎Theodore Roosevelt Bridge‎)

East end‎: ‎21st Street NE

Interstate 66 - Wikipedia

https://en.wikipedia.org/wiki/Interstate_66

Interstate 66 (I-66) is an Interstate Highway in the eastern United States. As indicated by its even route number, it runs in an east–west direction. ... Because I-66 is the only Interstate Highway running westfrom Washington, .... It proceeds east, has an interchange with Virginia Avenue NW, and terminates at 20th Street NW.